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Such histologic preparations include the upper portion of the functional layer of the endometrium, which is necessary for an accurate diagnosis.Use of this procedure considerably reduces the rate at which tissues are designated “insufficient for diagnosis.” The pathology requisition should contain all pertinent information, including date of last menstrual period.

In the most common terminology for dating the endometrial biopsy, day 1 is used as the first day of bleeding, and this is used in Figure 3 as the starting point.

It is not necessary to date the endometrium during the proliferative phase.

During this period, daily morphologic alterations are not sufficiently sensitive.

Its cyclic structural changes mirror changes in metabolic functions, and both are regulated by ovarian estradiol and progesterone.

Because of this interplay of structure, function, and ovarian hormonal stimuli, the endometrium is considered one of the most sensitive indicators of the hypothalamic-pituitary-ovarian hormonal axis.

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